Hello, i am desperate to fix this because nothing works.. i read all of the replies. 
	 
	 
	I already have latest spice2x (someone in the reply says to use this to fix), latest asphyxia (1.50c), updating it from 2021083100 to 2023042500 too 
	I also tried spice2x patches (Force bio2) and also use the Patcher from web (force bio2), tried A:F:A :A:G:A J:F:A all of them isnt working always BIO2 Cannot find and stuck on MAIN I/O. 
	 
	 
	Thanks in advance if someone is helping me.. i really desperate 
	 
	EDIT: I uploaded the log.txt for you guys to see 
	EDIT: I fixed it in spicex2 -> Advanced tab -> I/O Modules -> Enable All iO Modules 
	
 
	log.txt